How long does Simparica remain effective for dogs against ticks? - briefly
A single oral dose of Simparica protects dogs from tick infestations for approximately 35 days, effectively covering a full month. After that period, a new dose is required to maintain continuous protection.
How long does Simparica remain effective for dogs against ticks? - in detail
Simparica, containing the active ingredient sarolaner, provides continuous protection against a broad range of tick species when administered orally to dogs. After a single dose, therapeutic blood concentrations are achieved within 2–4 hours, and the drug remains at effective levels for the entire dosing interval. The labeled interval is 35 days, meaning that a dog will be protected from tick attachment and feeding throughout that period, provided the product is given on schedule.
Key points regarding efficacy duration:
- Onset of action: Parasites are killed within 8 hours of attachment, reducing the risk of disease transmission.
- Species coverage: Effective against Ixodes scapularis, Dermacentor variabilis, Rhipicephalus sanguineus, Amblyomma americanum, and several other common tick vectors.
- Pharmacokinetics: Sarolaner exhibits a half‑life of approximately 12 days; plasma concentrations decline gradually, maintaining activity until the next dose is due.
- Missed dose handling: If a dose is delayed, protection resumes after the next administration, but a gap longer than 7 days may allow tick infestations to develop.
- Age and weight considerations: Minimum weight for a single tablet is 2.8 kg; dosage is calibrated to body weight to ensure consistent plasma levels across the dosing window.
Veterinarians recommend adherence to the 35‑day schedule to sustain uninterrupted tick control, especially in regions with high tick prevalence or during peak activity seasons. Regular monitoring of the dog’s weight and health status ensures that the administered dose remains appropriate throughout the treatment course.