Understanding the Risk
What is Lyme Disease?
Lyme disease is a bacterial infection caused by Borrelia burgdorferi, transmitted to humans through the bite of infected Ixodes ticks. The pathogen enters the bloodstream during the feeding period, which typically lasts 24–48 hours. Early infection often produces a characteristic erythema migrans rash—expanding, round, and sometimes with central clearing—accompanied by flu‑like symptoms such as fever, chills, headache, fatigue, and muscle aches. If untreated, the infection may disseminate, leading to:
- Multiple rashes on other body sites
- Joint swelling, especially in knees
- Neurological manifestations (facial palsy, meningitis, peripheral neuropathy)
- Cardiac involvement (heart block, myocarditis)
Diagnosis relies on clinical assessment of rash and symptoms, supported by serologic testing for antibodies against B. burgdorferi. Confirmation is essential because early antibiotic therapy markedly reduces the risk of chronic complications. The standard treatment regimen includes doxycycline for adults and children over eight, or amoxicillin for younger children and pregnant patients, administered for 10–21 days depending on disease stage.
Understanding the disease’s progression informs the appropriate response when a tick is identified as a potential carrier: prompt removal, documentation of exposure, and immediate medical evaluation for possible prophylactic antibiotics.
How Ticks Transmit Lyme Disease
Ticks acquire the bacterium Borrelia burgdorferi while feeding on infected rodents or birds. The spirochete colonizes the tick’s midgut, where it persists through molting stages.
During the next blood meal, the tick inserts its hypostome into the host’s skin. Within 24–48 hours, the spirochetes migrate from the midgut to the salivary glands. Saliva, rich in anti‑inflammatory compounds, facilitates pathogen entry into the host’s bloodstream.
Transmission efficiency depends on attachment duration, tick species, and host immune response. Prompt removal—within a few hours—greatly reduces the risk of infection.
Key steps in the transmission cycle:
- Acquisition from infected reservoir hosts
- Persistence in the tick’s midgut across life stages
- Activation and migration to salivary glands during feeding
- Injection into the host via saliva after prolonged attachment
Understanding this pathway informs immediate actions when a potentially infected tick is found on a person.
Common Symptoms of Lyme Disease
Early Localized Stage
When a tick confirmed to carry Borrelia burgdorferi is removed, the first clinical concern is the early localized stage of Lyme disease. This stage typically appears within 3‑30 days after the bite and is characterized by a single expanding erythema migrans rash, often accompanied by flu‑like symptoms such as fever, headache, fatigue, and muscle aches. Prompt recognition and treatment at this point prevent progression to disseminated infection and chronic complications.
Immediate actions:
- Perform a thorough skin inspection to locate any erythema migrans lesion; document size and borders.
- Initiate oral doxycycline (100 mg twice daily for 10‑14 days) in adults and children ≥8 years; alternative regimens include amoxicillin or cefuroxime axetil for those with contraindications.
- Advise the patient to complete the full antibiotic course, even if symptoms resolve early.
- Schedule a follow‑up visit within one week to assess treatment response and monitor for emerging signs, such as additional rashes or neurological symptoms.
- Educate the patient on tick‑bite prevention measures for future exposure, including proper clothing, repellents, and regular body checks after outdoor activities.
Early intervention at the localized stage halts bacterial spread, reduces symptom duration, and minimizes the risk of long‑term joint, cardiac, or neurologic involvement.
Early Disseminated Stage
When a tick known to carry the Lyme‑causing bacterium bites, the infection can progress to the early disseminated stage within weeks. At this point the pathogen has spread beyond the skin, producing symptoms such as facial palsy, heart rhythm disturbances, meningitis, and migratory joint pain.
Prompt medical evaluation is essential. A clinician will:
- Obtain a detailed exposure history and symptom inventory.
- Order serologic testing (ELISA followed by Western blot) to confirm infection.
- Initiate an appropriate antibiotic regimen without delay.
Recommended antibiotic courses for early disseminated disease include doxycycline (100 mg twice daily for 14–21 days) or, for patients unable to tolerate doxycycline, ceftriaxone administered intravenously for 14–28 days. Treatment should begin as soon as the diagnosis is reasonably certain, even if serologic results are pending, to reduce the risk of organ involvement.
After completing therapy, patients must be re‑examined to verify symptom resolution. Persistent or recurrent manifestations warrant additional imaging, cardiac monitoring, or referral to a specialist. Documentation of treatment response guides decisions about extended or alternative antibiotic courses.
Continuous vigilance for new signs—especially cardiac arrhythmias, severe headaches, or joint swelling—remains critical during the weeks following therapy. Early reporting of such developments enables rapid intervention and minimizes long‑term complications.
Late Disseminated Stage
If a tick is identified as a carrier of the bacterium that causes Lyme disease and the patient exhibits signs of the late disseminated stage, immediate medical evaluation is essential. The clinician must confirm infection, initiate appropriate antimicrobial therapy, and arrange specialist follow‑up to address potential organ‑system involvement.
Laboratory confirmation typically includes two‑tier serology (enzyme‑linked immunosorbent assay followed by Western blot) or polymerase chain reaction testing of synovial fluid, cerebrospinal fluid, or skin biopsy specimens. Positive results, combined with clinical manifestations such as arthritis, meningitis, or cardiac conduction abnormalities, establish the diagnosis of late disseminated Lyme disease.
Treatment protocols for this stage recommend intravenous ceftriaxone 2 g daily for 14–28 days, or oral doxycycline 100 mg twice daily for a comparable period when intravenous therapy is contraindicated. The chosen regimen should be adjusted for renal or hepatic impairment, pregnancy, and patient tolerance.
After antimicrobial completion, systematic monitoring is required:
- Re‑evaluation of joint swelling and pain to detect persistent arthritis.
- Neurological assessment for residual cranial nerve palsy or peripheral neuropathy.
- Cardiac review, including electrocardiogram, to confirm resolution of conduction defects.
- Repeat serology at 3‑month intervals to document seroconversion trends.
Patients should receive education on recognizing relapse symptoms, adhering to the medication schedule, and preventing future tick exposure through protective clothing, repellents, and prompt tick removal. Referral to rheumatology, neurology, or cardiology is warranted when organ‑specific complications persist despite therapy.
Immediate Steps After a Positive Tick Test
Contacting Your Healthcare Provider
Information to Provide Your Doctor
When a tick that tests positive for the Lyme‑causing bacterium has bitten you, give your physician a complete, factual account. Include the following details:
- Date the bite occurred and estimated duration the tick remained attached.
- Exact location on the body where the tick was found.
- Species of tick, if identified, and any label from the testing laboratory confirming infection.
- Symptoms you are experiencing: rash (especially a bull’s‑eye pattern), fever, chills, headache, fatigue, joint pain, or neurological signs. Record the onset date for each symptom.
- Recent travel or outdoor activities that could have exposed you to ticks, specifying regions known for high Lyme prevalence.
- History of previous Lyme disease or treatment for related infections.
- Current medications, including antibiotics, antihistamines, or immunosuppressants, and any known drug allergies.
- Relevant medical conditions such as autoimmune disorders, pregnancy, or immunodeficiency.
Presenting this information enables prompt assessment, appropriate testing, and timely initiation of targeted therapy.
Discussing Treatment Options
If a tick is identified as carrying the Lyme‑causing bacterium, immediate medical evaluation is required. The first decision concerns prophylactic antibiotic therapy, which is indicated when the tick was attached for ≥ 36 hours, the local infection prevalence exceeds 20 percent, and the patient has no contraindications to the chosen drug.
Standard oral regimens
- Doxycycline 100 mg twice daily for 20 days (adults).
- Amoxicillin 500 mg three times daily for 20 days (children, pregnant patients, doxycycline‑intolerant adults).
- Cefuroxime axetil 500 mg twice daily for 20 days (alternative for doxycycline intolerance).
Early localized disease (erythema migrans or flu‑like symptoms) is treated with the same oral courses, initiated promptly after diagnosis.
Disseminated or neurologic involvement requires intravenous therapy: ceftriaxone 2 g daily for 14‑28 days, often combined with oral doxycycline if peripheral joint involvement is present.
Joint manifestations (Lyme arthritis) may be managed with oral doxycycline or amoxicillin for 28 days; refractory cases may need a second course or intravenous ceftriaxone.
Monitoring includes clinical assessment at 2‑4 weeks and serologic testing if symptoms persist. Persistent fatigue or neuropathic pain may warrant referral to a specialist for adjunctive therapies, such as anti‑inflammatory agents or physical rehabilitation.
Treatment selection must consider age, pregnancy status, drug allergies, and severity of presentation. Prompt initiation of the appropriate regimen reduces the risk of chronic complications.
Monitoring for Symptoms
Documenting Any Changes
When a tick is confirmed to carry the Lyme‑causing bacterium, systematic record‑keeping becomes a critical component of effective management. Precise documentation creates a clear timeline, supports clinical decisions, and facilitates communication with healthcare providers.
Begin by noting the exact date and location of the bite, the tick’s appearance, and any removal method used. Capture this information in a dedicated log or digital note, ensuring the entry is dated and includes the body region affected.
Track the emergence and progression of symptoms. For each new sign—such as rash, fever, joint pain, or neurological changes—record:
- Date of onset
- Description of intensity and characteristics
- Duration and any fluctuation
Include any over‑the‑counter or prescription medications taken, dosage, and start/end dates. Document each medical appointment, specifying the clinician’s name, the purpose of the visit, diagnostic tests ordered, and results received.
Maintain copies of laboratory reports, imaging studies, and prescription records. Organize these documents chronologically, either in a physical folder labeled with the patient’s name and the incident date or in a secure electronic file with consistent naming conventions.
Regularly review the compiled data. Identify patterns, such as symptom clusters or response to treatment, and share the summary with the treating physician before each follow‑up. This practice streamlines assessment, reduces recall errors, and enhances the likelihood of timely intervention.
Understanding the Incubation Period
The incubation period for Lyme disease—the interval between a tick bite and the appearance of clinical signs—typically spans 3 to 30 days, with most patients developing symptoms within 7 to 14 days. Early manifestations include erythema migrans, flu‑like fatigue, fever, headache, and muscle aches. Recognizing this timeframe helps differentiate Lyme disease from other tick‑borne infections and guides timely intervention.
When a tick is confirmed or strongly suspected to harbor the Lyme pathogen, immediate steps focus on preventing disease progression and monitoring for early signs. Prompt medical evaluation is essential because antibiotic prophylaxis is most effective when administered within 72 hours of removal and the tick has been attached for at least 36 hours.
- Seek professional medical advice as soon as possible.
- Discuss the possibility of a single dose of doxycycline (or an alternative for contraindicated patients).
- Record the date of the bite and any subsequent symptoms, noting especially the emergence of a rash or flu‑like illness within the expected incubation window.
- Continue observation for at least 30 days, reporting any new or worsening signs to a healthcare provider without delay.
Understanding the typical incubation period enables precise timing of treatment and vigilant symptom tracking, reducing the risk of advanced Lyme disease complications.
Treatment and Management
Antibiotic Regimens for Lyme Disease
Doxycycline
Doxycycline is the first‑line antibiotic for preventing Lyme disease after a bite from an infected tick. Administration should begin within 72 hours of removal and continue for 10 days. The standard adult regimen is 100 mg orally twice daily; for children weighing at least 45 kg, the same dose applies. For younger children, alternative agents are required because doxycycline can affect tooth development.
Key considerations when prescribing doxycycline:
- Verify that the tick was attached for ≥ 36 hours, a common threshold for prophylaxis eligibility.
- Exclude contraindications such as known hypersensitivity, pregnancy, or severe liver disease.
- Counsel patients on potential gastrointestinal upset, photosensitivity, and rare esophageal irritation; advise taking the medication with a full glass of water and remaining upright for 30 minutes.
- Monitor for signs of treatment failure, including expanding rash or flu‑like symptoms, which may necessitate a longer course or alternative therapy.
If the patient meets the timing and exposure criteria and has no contraindications, immediate initiation of doxycycline reduces the risk of early Lyme infection by approximately 85 %.
Amoxicillin
When a tick is identified as carrying the bacterium that causes Lyme disease, immediate medical assessment is required. The clinician will confirm exposure risk and, if early infection is suspected, may prescribe amoxicillin as first‑line oral therapy.
Amoxicillin dosage for adults typically ranges from 500 mg to 875 mg taken three times daily for 14–21 days. Pediatric dosing is weight‑based, usually 50 mg/kg per day divided into three doses. The medication must be taken with food to improve absorption and reduce gastrointestinal upset.
Key considerations for amoxicillin use include:
- Allergy to penicillins or cephalosporins excludes this option.
- Severe renal impairment necessitates dose adjustment.
- Concurrent use of oral contraceptives may reduce efficacy; alternative contraception should be considered.
- Completion of the full course prevents relapse and resistance.
If amoxicillin is contraindicated, doxycycline or cefuroxime axetil serve as alternative agents. Follow‑up serologic testing is advised 4–6 weeks after treatment to verify seroconversion and assess symptom resolution. Persistent or worsening manifestations warrant re‑evaluation and possible intravenous therapy.
Cefuroxime
Cefuroxime is an oral second‑generation cephalosporin commonly prescribed for early Lyme disease following a tick bite confirmed to carry Borrelia burgdorferi. The drug interferes with bacterial cell‑wall synthesis, leading to rapid bacterial death and preventing disease progression.
Typical regimen for adults:
- 500 mg twice daily for 14 days
Pediatric dosing:
- 30 mg/kg per day, divided into two doses, for 14 days (maximum 500 mg per dose)
Key considerations:
- Initiate therapy promptly after diagnosis to reduce risk of disseminated infection.
- Verify patient does not have a known cephalosporin allergy; alternative agents include doxycycline or amoxicillin.
- Monitor for gastrointestinal upset, rash, or signs of hypersensitivity; discontinue if severe reactions occur.
- Counsel patients that completing the full course is essential, even if symptoms improve early.
Cefuroxime achieves serum concentrations sufficient to eradicate B. burgdorferi in early-stage disease, making it a reliable option when doxycycline is contraindicated or not tolerated. Regular follow‑up ensures resolution of erythema migrans and prevents late manifestations such as arthritis or neurologic involvement.
Duration of Treatment
When an attached tick is confirmed to carry the bacterium that causes Lyme disease, treatment must begin promptly, and the length of therapy depends on the disease stage and patient characteristics.
For early localized infection, oral antibiotics are standard. The regimen usually consists of doxycycline 100 mg taken twice daily for 10–14 days. If doxycycline is contraindicated, amoxicillin or cefuroxime can be used at equivalent doses for the same period.
When the disease has progressed to disseminated forms—such as meningitis, cranial nerve palsy, or severe arthritis—intravenous ceftriaxone 2 g daily is prescribed. Therapy continues for 14–28 days, with the exact duration determined by clinical response and the specific organ involvement.
Special populations require adjusted protocols. Children younger than eight years receive amoxicillin 50 mg/kg per day, divided into three doses, for 14 days. Pregnant or breastfeeding patients are treated with amoxicillin or cefuroxime, avoiding doxycycline. Severe allergy to β‑lactam antibiotics may necessitate alternative agents such as clarithromycin, with a comparable treatment length.
After completing the antibiotic course, patients should be reassessed within two to four weeks. Persistent or recurrent symptoms may warrant an extended course of up to an additional four weeks, guided by laboratory results and specialist evaluation.
Follow-up Care
Post-Treatment Lyme Disease Syndrome (PTLDS)
Post‑treatment Lyme disease syndrome (PTLDS) refers to persistent or recurrent symptoms that last ≥ 6 months after completing an approved antibiotic regimen for Lyme disease. Common manifestations include fatigue, musculoskeletal pain, neurocognitive difficulties, and sleep disturbances. The syndrome affects an estimated 10‑20 % of patients who receive early treatment, and its pathophysiology remains under investigation.
When a tick is confirmed to carry the Lyme‑causing bacterium, immediate antibiotic therapy reduces the risk of acute infection, yet PTLDS may still develop. Early recognition of lingering symptoms enables timely management. Clinicians should:
- Conduct a thorough history and physical examination to differentiate PTLDS from other conditions.
- Order baseline laboratory tests (complete blood count, inflammatory markers, thyroid function) to exclude alternative etiologies.
- Refer patients with significant neurocognitive or psychiatric complaints to neurology or psychology specialists.
- Implement a multidisciplinary care plan that may include:
- Graded exercise programs tailored to individual tolerance.
- Cognitive‑behavioral therapy for persistent fatigue and mood disturbances.
- Pain management strategies such as non‑opioid analgesics, physical therapy, and, when appropriate, neuropathic agents.
- Schedule regular follow‑up visits to monitor symptom trajectory and adjust interventions.
Research indicates that PTLDS does not respond to additional prolonged antibiotic courses; therefore, treatment focuses on symptom mitigation and functional restoration. Patients should be educated about realistic expectations, the importance of pacing activities, and the availability of support resources.
Long-Term Monitoring
When a tick is identified as carrying the bacterium that causes Lyme disease, immediate removal and a course of prophylactic antibiotics may be recommended, but the responsibility does not end at treatment initiation. Long‑term monitoring is essential to detect delayed manifestations, assess treatment efficacy, and prevent complications.
First, schedule a follow‑up appointment with a healthcare provider within two to four weeks after exposure. During this visit, the clinician will review any emerging symptoms—such as fever, headache, fatigue, joint pain, or a characteristic skin rash—and may order serologic testing to establish a baseline antibody level. Baseline results serve as a reference for future comparisons.
Second, maintain a symptom diary for at least six months. Record daily observations of temperature, pain intensity, fatigue, and any new skin lesions. This systematic documentation enables the physician to identify subtle trends that might indicate evolving infection or treatment failure.
Third, adhere to a structured testing timeline:
- Weeks 2–4: Baseline enzyme‑linked immunosorbent assay (ELISA) and confirmatory Western blot if indicated.
- Months 3–6: Repeat serology to verify seroconversion or declining antibody titers.
- Months 12 and beyond: Additional testing if symptoms persist or recur, focusing on joint fluid analysis for arthritis or neuroimaging for neurological involvement.
Fourth, communicate any changes promptly. Early reporting of new or worsening signs allows rapid adjustment of therapy, such as extending antibiotic courses or initiating specialist referral.
Finally, consider preventive measures for future exposures: use repellents, wear protective clothing, and conduct regular body checks after outdoor activities. Consistent vigilance reduces the likelihood of repeated infection and supports overall health management.
Prevention and Future Precautions
Personal Protection Measures
Repellents
When a tick is identified as carrying the bacterium that causes Lyme disease, immediate steps focus on removal, medical evaluation, and prevention of further bites. Repellents form a critical component of the preventive strategy.
Effective repellents contain active ingredients approved by regulatory agencies. The most reliable options include:
- DEET (N‑N‑diethyl‑m‑toluamide) at concentrations of 20‑30 % for skin application; higher percentages increase duration without improving protection.
- Picaridin (KBR‑3023) at 10‑20 % concentration; comparable efficacy to DEET with a milder odor.
- IR3535 (ethyl butylacetylaminopropionate) at 20 % concentration; suitable for children and pregnant individuals when used as directed.
- Permethrin (synthetic pyrethroid) applied to clothing, shoes, and gear at 0.5 % concentration; provides residual protection after washing up to six times.
Application guidelines:
- Apply skin repellents 30 minutes before exposure; reapply every 4–6 hours or after swimming, sweating, or towel drying.
- Treat clothing and equipment with permethrin by spraying evenly; allow to dry completely before wearing.
- Avoid applying repellents to broken skin, eyes, or mucous membranes; wash off after returning indoors.
- Store products in a cool, dry place; keep out of reach of children.
Choosing the appropriate repellent depends on activity duration, environmental conditions, and personal sensitivities. Combining skin‑applied repellents with permethrin‑treated clothing maximizes protection against infected ticks and reduces the risk of additional exposure.
Protective Clothing
Protective clothing serves as the first line of defense when a tick capable of transmitting Lyme disease is encountered in the field. Choose garments that minimize skin exposure and create a barrier that deters tick attachment.
- Wear long‑sleeved shirts and long trousers; tuck the shirt into the waistband and the pant legs into socks or boots.
- Select fabrics with a tight weave; synthetic blends reduce friction that encourages ticks to climb.
- Apply a permethrin treatment to outerwear; the insecticide remains effective after several washes and kills ticks on contact.
- Opt for light colors such as beige or khaki; they make it easier to spot ticks before they attach.
- Use gaiters or ankle covers when walking through dense vegetation; they prevent ticks from reaching the lower legs.
Inspect clothing immediately after exposure. Remove any visible ticks with tweezers, grasping close to the skin and pulling straight upward. Wash and dry the garments at high temperature to eliminate any remaining arthropods. By adhering to these practices, the risk of infection from a Lyme‑carrying tick is substantially reduced.
Tick Checks
Perform thorough tick inspections immediately after outdoor activities. Use fine‑tipped tweezers to grasp the tick as close to the skin as possible, pull upward with steady pressure, and avoid crushing the body. After removal, clean the bite area with antiseptic.
If laboratory testing or a reputable source confirms that the tick carries the Lyme‑causing bacterium, follow these steps:
- Contact a healthcare professional within 24 hours; early antibiotic treatment reduces the risk of severe disease.
- Record the date of the bite, the tick’s developmental stage, and any symptoms such as rash, fever, or joint pain.
- Retain the tick in a sealed container for possible further analysis, but do not reuse it for diagnosis.
- Monitor the bite site and overall health for up to 30 days; report any expanding rash or flu‑like symptoms promptly.
Consistent self‑examination and rapid removal remain the most effective measures to prevent infection and to guide timely medical intervention.
Yard and Pet Management
Landscaping Tips
Ticks that may transmit Lyme disease thrive in unmanaged vegetation. Maintaining a tidy yard reduces the likelihood of encountering infected arthropods.
- Keep grass trimmed to 2‑3 inches; short blades expose fewer microclimates for tick development.
- Remove leaf piles, brush, and tall weeds where ticks hide.
- Install a mulch barrier at least three feet wide between lawn and wooded areas; wood chips or gravel create a dry zone unattractive to ticks.
- Encourage natural predators such as birds and beneficial insects by providing nesting boxes and diverse plantings.
- Limit deer access with fencing or deer‑deterrent plants; deer are primary hosts for adult ticks.
If a tick suspected of carrying Lyme disease is found attached, follow a precise protocol. Use fine‑pointed tweezers to grasp the tick as close to the skin as possible, pull upward with steady pressure, and avoid crushing the body. Disinfect the bite site with alcohol or iodine. Preserve the tick in a sealed container for identification if required. Contact a healthcare professional promptly; early antibiotic treatment reduces the risk of severe complications. Monitor the bite area for rash or flu‑like symptoms and report any changes to a medical provider without delay.
Tick Control for Pets
If a tick attached to a dog or cat tests positive for the Lyme‑causing bacterium, immediate action protects the animal and reduces the chance of transmission.
First, remove the tick promptly with fine‑point tweezers, grasping close to the skin and pulling straight upward to avoid leaving mouthparts. Disinfect the bite site and wash hands thoroughly.
Second, schedule a veterinary examination without delay. The veterinarian will assess the pet’s health, consider a prophylactic antibiotic regimen, and discuss vaccination options where available.
Third, implement a comprehensive tick‑prevention program to stop future infestations:
- Apply a veterinarian‑approved topical or oral acaricide according to the product’s schedule.
- Use a tick‑preventive collar that releases active ingredients for several months.
- Maintain the yard by trimming grass, removing leaf litter, and treating high‑risk zones with an appropriate acaricide.
- Inspect the pet daily, especially after outdoor activities, and remove any attached ticks promptly.
Finally, monitor the pet for signs of Lyme disease, such as fever, loss of appetite, lameness, or joint swelling, and report any symptoms to the veterinarian immediately. Early detection and consistent control measures minimize health risks and protect both the pet and its human companions.
When to Seek Emergency Care
If a tick known to be infected with the bacterium that causes Lyme disease is removed, immediate medical attention is not always required, but certain symptoms demand urgent evaluation. Delay can increase the risk of severe complications, including cardiac involvement, neurological deficits, and systemic infection.
Seek emergency care if any of the following occur within hours to days after the bite:
- Rapidly spreading redness or swelling that extends beyond the bite site, especially if accompanied by fever.
- Severe headache, stiff neck, or sudden confusion, indicating possible meningitis or encephalitis.
- Chest pain, palpitations, shortness of breath, or fainting, which may signal Lyme carditis or arrhythmia.
- Persistent high fever (≥ 101 °F / 38.3 °C) that does not respond to over‑the‑counter antipyretics.
- Neurological deficits such as facial droop, weakness, numbness, or loss of coordination.
- Unexplained joint swelling or intense pain, particularly if it worsens rapidly.
If none of these signs are present, arrange prompt outpatient evaluation with a primary‑care provider or an infectious‑disease specialist. Initiate appropriate antibiotic therapy as soon as possible to reduce the likelihood of long‑term sequelae.