How long does Simparica tablet take to work against ticks in dogs? - briefly
Simparica starts killing ticks within about 8 hours of a single oral dose, and achieves complete effectiveness by the 24‑hour mark.
How long does Simparica tablet take to work against ticks in dogs? - in detail
Simparica (sarolaner) is an oral acaricide that begins to affect attached ticks within a short period after ingestion. Peak plasma concentrations are reached approximately 2–4 hours post‑dose, and laboratory studies show that 90 % of ticks are killed by the 4‑hour mark. In field conditions, most owners observe dead or detached ticks within 6–8 hours of administration.
Key factors influencing the speed of action:
- Dose accuracy – the tablet is calibrated by the dog’s weight; under‑dosing can delay efficacy.
- Tick species – fast‑acting species such as Ixodes scapularis are eliminated within 4 hours, whereas larger species like Dermacentor variabilis may require up to 8 hours for complete kill.
- Feeding status – a full meal enhances absorption, slightly shortening the time to effect.
- Health of the dog – severe liver or gastrointestinal disease can slow drug metabolism, extending the onset.
Pharmacokinetic data indicate that sarolaner binds strongly to plasma proteins, maintaining therapeutic levels for at least 35 days, which provides continuous protection without a need for re‑dosing during that interval. After the initial dose, subsequent administrations maintain the same rapid tick‑killing profile.
Practical expectations:
- Administer the tablet with food.
- Observe for tick mortality within 4–8 hours.
- If live ticks persist beyond 24 hours, consult a veterinarian to rule out resistance or dosing errors.
Overall, Simparica delivers a swift kill of attached ticks, typically within a few hours, and sustains protective concentrations for a full month.