How does fiprist work against fleas? - briefly
Fiprist disrupts flea nervous function by blocking GABA‑gated chloride channels, causing uncontrolled nerve activity, paralysis, and death. The ingredient is absorbed transdermally and circulates systemically, delivering weeks of continuous protection.
How does fiprist work against fleas? - in detail
Fiprist is an isoxazoline compound formulated for oral administration to dogs and cats. After ingestion, it is absorbed into the bloodstream and distributed throughout the body, including the epidermis and hair follicles where fleas feed.
The active molecule interferes with two ligand‑gated chloride channels that are essential for insect nervous system function:
- GABA‑gated chloride channels
- Glutamate‑gated chloride channels
By binding to these receptors, fiprist blocks chloride ion influx, preventing neuronal hyperpolarization. The resulting uncontrolled neuronal firing produces rapid muscle spasms, loss of coordination, and death of the parasite.
Fleas encounter the drug primarily through blood ingestion while attached to the host. Systemic exposure ensures that every feeding event delivers a lethal dose, eliminating existing infestations and preventing new ones from establishing.
Key pharmacological characteristics:
- Oral bioavailability > 90 %
- Peak plasma concentration reached within 2–4 hours
- Half‑life of 10–14 days, providing month‑long protection with a single dose
- Selectivity for arthropod receptors, yielding a wide safety margin for mammals
Resistance development is limited because the dual‑target mechanism differs from older classes such as pyrethroids and organophosphates. Field studies report sustained efficacy against common flea species, including Ctenocephalides felis and C. canis.
Overall, the drug’s systemic delivery, high affinity for insect-specific chloride channels, and prolonged circulation combine to deliver rapid, persistent flea control without compromising host safety.