How does Dichlorvos Neo act on bedbugs? - briefly
Dichlorvos Neo, an organophosphate insecticide, inhibits acetylcholinesterase in bedbugs, causing acetylcholine buildup that rapidly induces paralysis and death.
How does Dichlorvos Neo act on bedbugs? - in detail
Dichlorvos Neo is an organophosphate aerosol formulated for rapid knock‑down of Cimex lectularius. The active ingredient, dichlorvos, inhibits acetylcholinesterase by phosphorylating the enzyme’s serine hydroxyl group. This blockade prevents the breakdown of acetylcholine at synaptic junctions, causing continuous neuronal stimulation, muscular convulsions, and eventual paralysis.
When the aerosol contacts the insect’s cuticle, the compound penetrates through the thin exoskeleton and reaches the nervous system within seconds. Systemic absorption leads to:
- Immediate hyperexcitation of motor neurons
- Loss of coordinated movement
- Respiratory failure due to paralysis of the tracheal musculature
- Death typically within 5–30 minutes, depending on dose and life stage
Dichlorvos Neo also releases a vapor phase that diffuses in confined spaces, allowing contact with hidden bedbugs in cracks, crevices, and fabric folds. The vapor concentration remains above the lethal threshold for several hours, extending efficacy beyond the initial spray.
Resistance mechanisms reported in other insects—such as increased acetylcholinesterase expression or detoxifying enzyme activity—are less documented in bedbugs, but repeated sub‑lethal exposure could select for tolerant populations. Therefore, label recommendations advise a single thorough application followed by a re‑treatment after 7–10 days to target newly emerged individuals.
Safety considerations include:
- Volatile nature requires ventilation after application
- Protective equipment (gloves, mask) for applicators
- Avoidance of direct inhalation and skin contact to prevent human cholinergic toxicity
Overall, Dichlorvos Neo delivers fast-acting neurotoxic action through acetylcholinesterase inhibition, leading to rapid paralysis and mortality of bedbugs, while the vapor component ensures coverage of concealed infestations.