How does delcid act on ticks? - briefly
Delcid binds to voltage‑gated sodium channels in tick nerve cells, causing uncontrolled depolarisation and paralysis. The rapid knock‑down effect results in death of the parasite within minutes.
How does delcid act on ticks? - in detail
Delcid, a synthetic acaricide, exerts its lethal effect on ticks through a multi‑stage biochemical disruption. The compound penetrates the cuticle and distributes via the hemolymph, reaching neuronal and muscular tissues. Primary actions include:
- Inhibition of acetylcholinesterase, leading to accumulation of acetylcholine at synaptic junctions and continuous nerve impulse transmission.
- Blockade of voltage‑gated sodium channels, causing prolonged depolarization, loss of coordinated muscle contraction, and paralysis.
- Disruption of mitochondrial respiration by interfering with electron‑transport chain complexes, resulting in ATP depletion and cellular energy failure.
Secondary consequences involve oxidative stress induction, manifested by elevated reactive oxygen species and lipid peroxidation, which further compromise membrane integrity. The combined neurotoxic and metabolic disturbances culminate in rapid immobilization and death of the tick.
Resistance management relies on rotating delcid with acaricides possessing distinct modes of action, monitoring susceptibility through bioassays, and adhering to label‑specified concentration ranges to avoid sub‑lethal exposure. Proper application—direct contact with the host animal or environmental treatment—ensures sufficient uptake by the target organism, maximizing efficacy while minimizing environmental impact.