How does bipin affect a tick? - briefly
Exposure to bipin disrupts the tick’s nervous system, inducing rapid paralysis and mortality. It also impairs feeding behavior, shortening the duration of host attachment.
How does bipin affect a tick? - in detail
Bipin, a synthetic acaricide, interacts with tick nervous systems by binding to voltage‑gated sodium channels. This binding prolongs channel opening, leading to uncontrolled neuronal firing and paralysis. The compound also inhibits acetylcholinesterase, causing accumulation of acetylcholine at synaptic clefts, which intensifies muscular hyperactivity before collapse.
The physiological cascade includes:
- Disruption of ion homeostasis → membrane depolarization.
- Overstimulation of motor neurons → spastic contractions.
- Failure of respiratory muscles → asphyxiation.
- Secondary metabolic stress → depletion of ATP reserves.
Laboratory assays demonstrate dose‑dependent mortality. At concentrations of 0.5 µg/mL, 70 % of examined specimens exhibit loss of coordination within 30 minutes; increasing the dose to 2 µg/mL reduces survival time to under 10 minutes. Field trials confirm reduced tick populations on treated hosts without observable resistance after three application cycles.
Environmental persistence is limited; bipin degrades under ultraviolet light with a half‑life of approximately 12 days in soil, minimizing non‑target exposure. Toxicological profiles indicate low mammalian toxicity, as the compound’s affinity for insect‑specific sodium channel subtypes exceeds that for vertebrate isoforms.
In summary, bipin exerts lethal effects on ticks through simultaneous neurotoxic mechanisms, rapid onset of paralysis, and efficient metabolic disruption, while maintaining a favorable safety margin for mammals and the environment.